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FK-506

Supplier:
Catalogue number:
10-1103-02
Size:
50 mg
Product is available in:
  • USA
  • Canada
$180.00 Shipping is calculated in checkout

FKBP inhibitor. mTORC1 pathway members interact with SARS-CoV-2 N and Orf8 proteins. Gordon et al. bioRxiv, Mar 23 2020, https://doi.org/10.1101/2020.03.22.002386.

  • Datasheet:   view or download
  • Applications:Approved drug (U.S.) that could be repurposed
Product Type:

Biochemicals & reagents

CAS Number:

104987-11-3

Range:

1) Yu et al. (2006), Effects of cyclosporine A, FK506 and rapamycin on clacineurin phosphatase activity in mouse brain; IUBMB Life, 58 429

Limit of Detection:

804.04

Storage Temperature:

-20°C

Additional Information:

FK-506 induces immunosuppression by inhibiting T cell proliferation. It aso inhibits FKBP12 and calcineurin (IC50 ~ 1 nM) and is cell permeable.