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Cycloheximide-N-ethylethanoate

Supplier:
Catalogue number:
10-1062-02
Size:
25 mg
Product is available in:
  • USA
  • Canada
$260.00 Shipping is calculated in checkout

FKBP12 inhibitor. mTORC1 pathway members interact with SARS-CoV-2 N and Orf8 proteins.

Product Type:

Biochemicals & reagents

CAS Number:

not found

Range:

1) Christner et al. (1999), Synthesis and cytotoxic evaluation of cycloheximide derivatives as potential inhibitors if FKBP12 with neuroregenerative properties; J. Med. Chem., 42 3615 2) Norville et al. (2011), The structure of a Burkholderia pseudomallei immunophilin-inhibitor complex reveals new approaches to antimicrobial development; Biochem. J., 437 413

Limit of Detection:

367.44

Storage Temperature:

-20°C (des.)

Additional Information:

Cycloheximide-N-ethylethanoate is a FKBP12 inhibitor (IC50=4.4 µM) with neuroregenerative properties but does not inhibit protein synthesis (as does cycloheximide) (1). This compound mimics a helical peptide in target proteins for binding to the immunophillin Mip homolog, BpML1 (Burkholderia pseudomallei Mip-like protein (1,2)