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GBR-12909 2HCl

Supplier:
Catalogue number:
10-1458-01
Size:
10 mg
Product is available in:
  • USA
  • Canada
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Dopamine reuptake inhibitor. Sigma receptor agonist (SARS-CoV-2 Nsp6 protein interacts with the Sigma receptor).

  • Datasheet:   view or download
  • Applications:Clinical trials showed no serious adverse events, but lack of efficacy for cocaine addiction; could be repurposed
Product Type:

Biochemicals & reagents

CAS Number:

67469-78-7

Range:

1) Andersen et al. (1989), The dopamine inhibitor GBR 12909: selectivity and molecular mechanism of action; Eur. J. Pharmacol., 166 493 2) Contreras et al. (1990), GBR-12909 and fluspirilene potently inhibited binding of [3H] (+)3-PPP to sigma receptors in rat brain; Life Sci., 47 PL133 3) Yorgason et al. (2011), Low and high affinity dopamine transporter inhibitors block dopamine uptake within 5 sec of intravenous injection; Neuroscience, 182 125

Limit of Detection:

523.5

Storage Temperature:

Room Temperature

Additional Information:

GBR-12909 2HCl is a potent and selective inhibitor of dopamine reuptake (Ki = 1 nM) with greater than 100 fold selectivity over serotonin and noradrenaline (1) which also acts as a potent sigma receptor ligand (2) and is a very fast acting via i.v. administration (3).