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Daunorubicin HCl

Supplier:
Catalogue number:
10-2429-01
Size:
10 mg
Product is available in:
  • USA
  • Canada
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DNA damaging agent; Autophagy modulator. Targets Multidrug resistance-associated protein 1 (MRP1), which interacts with SARS-CoV-2 Orf9c. Gordon et al. bioRxiv, Mar 23 2020, https://doi.org/10.1101/2020.03.22.002386.

  • Datasheet:   view or download
  • Applications:Approved drug (U.S.) that could be repurposed
Product Type:

Biochemicals & reagents

CAS Number:

23541-50-6

Range:

1) Laurent and Jaffrezou (2001), Signaling pathways activated by daunorubicin; Blood 98 913 2) Noel et al. (2008), Parallel improvement of sodium and chloride transport defects by miglustat (n-butyldeoxynojyrimicin) in cystic fibrosis; J. Pharmacol. Exp. Ther., 325 1016 3) Masquelier et al. (2004), Relationship between daunorubicin concentration and apoptosis induction in leukemic cells; Biochem.Pharmacol. 67 1047 4) Han et al. (2011), Autophagy inhibition enhances daunorubicin-induced apoptosis in K562 cells; PLoS One 6 e28491

Limit of Detection:

563.98

Storage Temperature:

-20°C (des.)

Additional Information:

Daunorubicin is an antitumor antibiotic used in the treatment of acute myeloid leukemias (1). This compound induces DNA damage by intercalation (2), it also induces apoptosis in a variety of cell lines (3) and the inhibition of autophagy with chloroquine enhances daunorubicin-induced apoptosis in K562 cells (4). This compound is also cell permeable.