www.mayflowerbio.com
Sales & Support: 314-485-5210

*

Ebselen

Supplier:
Catalogue number:
10-2288-01
Size:
10 mg
Product is available in:
  • USA
  • Canada
$28.00 Shipping is calculated in checkout

Glutathione peroxidase mimic. Inhibits SARS-CoV-2 chymotrypsin-like protease (3CLpro). Jin et al. Nature, Apr 9 2020, https://doi.org/10.1038/s41586-020-2223-y; Ma et al. bioRxiv, May 8 2020, https://doi.org/10.1101/2020.04.20.051581.

  • Datasheet:   view or download
  • Applications:In clinical trials for other indication(s)
Product Type:

Biochemicals & reagents

CAS Number:

60940-34-3

Range:

1) Schewe et al. (1995), Molecular actions of ebselen – an anti-inflammatory antioxidant; Gen. Pharmacol., 26 1153 / 2) Parnham et al. (2000), Ebselen: prospective therapy for cerebral ischaemia; Expert. Opin. Investig. Drugs, 9 607 / 3) Masumoto et al. (1996), Kinetic study of the reaction of ebselen with peroxynitite; FEBS Lett., 398 179 / 4) Nakamura et al. (2002), Ebselen, a glutathione peroxidase mimetic seleno-organic compound, as a multifunctional antioxidant. Implication for inflammation-associated carcinogenesis; J. Biol. Chem., 277 2687

Limit of Detection:

274.18

Storage Temperature:

Room Temperature

Additional Information:

Ebselen is a novel nontoxic selenium-containing multifunctional antioxidant and anti-inflammatory agent (1) which isplays protective effects in reperfusion injury and stroke (2). This compound is an excellent scavenger of peroxynitrite (3), acts as a glutathione peroxidase mimetic (4) and is cell permeable.