Ebselen

Supplier:

Focus Biomolecules

Catalogue number:

10-2288-02

Size:

100 mg

Product is available in:

$100.00

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Glutathione peroxidase mimic. Inhibits SARS-CoV-2 chymotrypsin-like protease (3CLpro). Jin et al. Nature, Apr 9 2020, https://doi.org/10.1038/s41586-020-2223-y; Ma et al. bioRxiv, May 8 2020, https://doi.org/10.1101/2020.04.20.051581.

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Datasheet: view or download
Applications:In clinical trials for other indication(s)

Product Type:

Biochemicals & reagents

CAS Number:

60940-34-3

Range:

1) Schewe et al. (1995), Molecular actions of ebselen – an anti-inflammatory antioxidant; Gen. Pharmacol., 26 1153 / 2) Parnham et al. (2000), Ebselen: prospective therapy for cerebral ischaemia; Expert. Opin. Investig. Drugs, 9 607 / 3) Masumoto et al. (1996), Kinetic study of the reaction of ebselen with peroxynitite; FEBS Lett., 398 179 / 4) Nakamura et al. (2002), Ebselen, a glutathione peroxidase mimetic seleno-organic compound, as a multifunctional antioxidant. Implication for inflammation-associated carcinogenesis; J. Biol. Chem., 277 2687

Limit of Detection:

274.18

Storage Temperature:

Room Temperature

Additional Information:

Ebselen is a novel nontoxic selenium-containing multifunctional antioxidant and anti-inflammatory agent (1) which isplays protective effects in reperfusion injury and stroke (2). This compound is an excellent scavenger of peroxynitrite (3), acts as a glutathione peroxidase mimetic (4) and is cell permeable.