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1 mg
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HDAC inhibitor. HDAC2 interacts with SARS-CoV-2 Nsp5. Gordon et al. bioRxiv, Mar 23 2020, https://doi.org/10.1101/2020.03.22.002386.

Product Type:

Biochemicals & reagents

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1) Darkin-Rattray, et al. (1996) Apicidin: a novel antiprotozoal agent that inhibits parasite histone deacetylase Proc.Nat.Acad.Sci. USA 93 13143 / 2) Han, et al. (2000) Apicidin, a histone deacetylase inhibitor, inhibits proliferation of tumor cells via induction of p21WAF1/Cip1 and gelsolin Cancer Res. 60 6068 / 3) Kim, et al. (2007) Regulation of the HIF-1alpha stability by histone deacetylases Oncol. Rep. 17 647

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Apicidin is a fungal toxin that is a potent, cell permeable inhibitor of histone deacetylases (HDAC’s) (1). This compound also displays antitumor properties by inducing changes in p21WAF1/Cip1 and gelsolin gene expression causing cell cycle arrest in the G1 phase (2). It also dramatically decreases HIF-1α protein levels and transcriptional activity in human and mouse tumor cell lines (3).