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Catalogue number:
5 mg
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FKBP ligand. mTORC1 pathway members interact with SARS-CoV-2 N and Orf8 proteins.

Product Type:

Biochemicals & reagents

CAS Number:



1) Hatanaka et al. (1988), FR-900520 and FR-900523, novel immunosupressants isolated from a Streptomyces. II. Fermentation, isolation and physio-chemical and biological characteristics; J. Antibiot. (Tokyo), 41 1592 2) Petros et al. (1991), NMR studies of an FK506 analogue [U-13C]ascomycin, bound to FKBP: conformation and regions of ascomycin involved in binding; J. Med. Chem., 34 2925 3) Mollison et al. (1999), A macrolactam inhibitor of T helper type 1 and T helper type 2 cytokine biosynthesis for topical treatment of inflammatory skin diseases; J. Invest. Dermatol., 112 729

Limit of Detection:


Storage Temperature:

-20°C (des.)

Additional Information:

Ascomycin is an analog of FK-506 which is a potent immunosuppressant (1). This compound binds to FKBP122 and inhibits calcineurin and NFAT. It also displays antiinflammatory effects in skin diseases (3), is cell permeable and active in vivo.