www.mayflowerbio.com
Sales & Support: 314-485-5210

*

IBMX

Supplier:
Catalogue number:
10-1008-01
Size:
100 mg
Product is available in:
  • USA
  • Canada
$30.00 Shipping is calculated in checkout

PDE inhibitor (pan-spec)

Product Type:

Biochemicals & reagents

CAS Number:

28822-58-4

Alternative Names:

3-Isobutyl-1-methylxanthine

Range:

1) Beavo et al. (1970), Effects of xanthine derivatives on lipolysis and on adenosine 3’,5’-monophosphate phosphodiesterase activity; Mol. Pharmacol., 6 597 / 2) Tomes et al. (1993), Isobutylmethylxanthine and other classical cyclic nucleotide phosphodiesterase inhibitors affect cAMP-dependent protein kinase activity; Cell Signal., 5 615 / 3) Soderling et al. (2000), Regulation of cAMP and cGMP signaling: new phosphodiesterases and new functions; Curr. Opin. Cell Biol., 12 174 / 4) Daly et al. (1987), Adenosine receptors: development of selective agonists and antagonists; Prog. Clin. Biol. Res., 230 41

Limit of Detection:

222.25

Storage Temperature:

Room Temperature

Additional Information:

IBMX (28822-58-4) is a pan-specific inhibitor of phosphodiesterases (IC50=2-50 µM). Inhibition of PDEs leads to increased concentration of intracellular cAMP which activates PKA2. IBMX does not inhibit PDE8 or PDE93. Weak adenosine receptor antagonist4.

Related Content: