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Doxorubicin HCl

Supplier:
Catalogue number:
10-2130-02
Size:
50 mg
Product is available in:
  • USA
  • Canada
$95.00 Shipping is calculated in checkout

DNA damaging agent

Product Type:

Biochemicals & reagents

CAS Number:

25316-40-9

Alternative Names:

Adriamycin; NSC-123127

Range:

1) Zeman et al. (1998), Characterization of covalent adriamycin-DNA adducts; Proc. Natl. Acad. Sci., 95 11561 2) Katoh et al. (1998), Vascular endothelial growth factor inhibits apoptotic death in hematopoietic cells after exposure to chemotherapeutic drugs by inducing MCL1 acting as an antiapoptotic factor; Cancer Res., 58 5565 3) Perez et al. (2011), Anti-MDR-1 siRNA restores chemosensitivity in chemoresistant breast carcinoma and osteosarcoma cell lines; Anticancer Res., 31 2813

Limit of Detection:

579.99

Storage Temperature:

-20°C

Additional Information:

Doxorubicin HCl (25316-40-9) is an antitumor antibiotic. Induces DNA damage by intercalation1 and inhibition of topoisomerase II. Doxorubicin HCl induces apoptosis in a variety of cell lines2. Acts as a substrate for MDR13. Cell permeable.

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