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Doxorubicin HCl

Doxorubicin HCl
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Size: 10 mg
$45.00
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Catalogue number:
10-2130-01
Name:
Doxorubicin HCl
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DNA damaging agent

Data sheet:

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Applications:


DNA damaging agent

Product Type:
Biochemicals & reagents
CAS Number:
25316-40-9
Alternative Names:
Adriamycin; NSC-123127
Storage Temp:
-20°C
Molecular Weight:
579.99
Reference:
1) Zeman et al. (1998), Characterization of covalent adriamycin-DNA adducts; Proc. Natl. Acad. Sci., 95 11561 2) Katoh et al. (1998), Vascular endothelial growth factor inhibits apoptotic death in hematopoietic cells after exposure to chemotherapeutic drugs by inducing MCL1 acting as an antiapoptotic factor; Cancer Res., 58 5565 3) Perez et al. (2011), Anti-MDR-1 siRNA restores chemosensitivity in chemoresistant breast carcinoma and osteosarcoma cell lines; Anticancer Res., 31 2813
Additional Information:
Doxorubicin HCl (25316-40-9) is an antitumor antibiotic. Induces DNA damage by intercalation1 and inhibition of topoisomerase II. Doxorubicin HCl induces apoptosis in a variety of cell lines2. Acts as a substrate for MDR13. Cell permeable.