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Z-VAD-FMK

Z-VAD-FMK
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Size: 1 mg
$98.00
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Catalogue number:
10-2614-01
Name:
Z-VAD-FMK
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Caspase inhibitor

Data sheet:

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Applications:


Caspase inhibitor

Product Type:
Biochemicals & reagents
CAS Number:
187389-52-2
Alternative Names:
ZVAD(OMe)-FMK
Storage Temp:
-20°C (des.)
Molecular Weight:
467.5
Reference:
1) Slee et al. (1996), Benzyloxycarbonyl-Val-Ala-ASP (OMe) fluoromethylketone (Z-VAD.FMK) inhibits apoptosis by blocking the processing of CPP32; Biochem. J., 315 21 2) Kunstle et al. (1997), ICE-protease inhibitors block murine liver injury and apoptosis caused by CD95 or by TNF-alpha; Immunol. Lett., 55 5 3) Garcia-Calvo et al. (1998), Inhibition of human caspases by peptide based and macromolecular inhibitors; J. Biol. Chem., 273 32608
Additional Information:
Z-VAD-FMK (187389-52-2), cell-permeable, methyl ester form. Potent, irreversible pan-caspase inhibitor. Inhibits caspase activity and apoptosis induction in a variety of cell types (IC50 = 1.5 μM). Active in vivo.