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Z-VAD-FMK

Supplier:
Catalogue number:
10-2614-01
Size:
1 mg
Product is available in:
  • USA
  • Canada
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Caspase inhibitor

Product Type:

Biochemicals & reagents

CAS Number:

187389-52-2

Alternative Names:

ZVAD(OMe)-FMK

Range:

1) Slee et al. (1996), Benzyloxycarbonyl-Val-Ala-ASP (OMe) fluoromethylketone (Z-VAD.FMK) inhibits apoptosis by blocking the processing of CPP32; Biochem. J., 315 21 2) Kunstle et al. (1997), ICE-protease inhibitors block murine liver injury and apoptosis caused by CD95 or by TNF-alpha; Immunol. Lett., 55 5 3) Garcia-Calvo et al. (1998), Inhibition of human caspases by peptide based and macromolecular inhibitors; J. Biol. Chem., 273 32608

Limit of Detection:

467.5

Storage Temperature:

-20°C (des.)

Additional Information:

Z-VAD-FMK (187389-52-2), cell-permeable, methyl ester form. Potent, irreversible pan-caspase inhibitor. Inhibits caspase activity and apoptosis induction in a variety of cell types (IC50 = 1.5 μM). Active in vivo.

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