α1 adrenergic antagonist. Limits 'cytokine storm' induced during ARDS (acute respiratory distress syndrome). Konig et al. MedRxiv, Apr 8 2020, https://doi.org/10.1101/2020.04.02.20051565.
- Applications:"Cytokine storm" drug (approved, U.S.), that could be repurposed
Biochemicals & reagents
Prazosin is an antihypertensive drug that acts as an antagonist to the alpha1-adrenergic receptors (1). Kis were 9.9 nM for each subtype in CHO cells expressing alpha1A-, alpha1B-, or alpha1D-AR (2).