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Sigma-2 agonist; Antihistamine. Inhibits SARS-CoV-2 in cells. Gordon et al. Nature, Apr 30 2020, https://doi.org/10.1038/s41586-020-2286-9; Riva et al. bioRxiv, Apr 17 2020, https://doi.org/10.1101/2020.04.16.044016.
- Datasheet: view or download
- Applications:Approved but withdrawn (U.S.)
Biochemicals & reagents
1) Richards et al. (1984), Astemizole. A review of its pharmacodynamic properties and therapeutic efficacy; Drugs, 28 38 / 2) Laduron et al. (1982), In vitro and in vivo binding characteristics of a new long-acting histamine H1 antagonist, astemizole; Mol. Pharmacol., 21 294
Limit of Detection:
Astemizole is an antagonist at the histamine H1 receptor.