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Bafilomycin A1

Supplier:
Catalogue number:
10-2060-02
Size:
1 mg
Product is available in:
  • USA
  • Canada
$160.00 Shipping is calculated in checkout

Vacuolar H+ ATPase inhibitor; Autophagy modulator. V1-ATPase subunits interact with SARS-CoV-2 Nsp6 and M; Inhibits SARS-CoV-2 in cells. Gordon et al. bioRxiv, Mar 23 2020, https://doi.org/10.1101/2020.03.22.002386; Gordon et al. Nature, Apr 30 2020, https://doi.org/10.1038/s41586-020-2286-9.

Product Type:

Biochemicals & reagents

CAS Number:

88899-55-2

Range:

1) Werner et al. (1984) Metabolic products of microorganisms. Bafilomycins, a new group of macrolide antibiotics. Production, isolation, chemical structure and biological activity. J.Antibiot. 37 110 / 2) Drose and Altendorf (1997) Bafilomycins and concanamycins as inhibitors of V-ATPase and P-ATPase J.Exp.Biol. 200 1 / 3) Yamamoto et al. (1998) Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells Cell Struct.Func. 23 33

Limit of Detection:

622.84

Storage Temperature:

-20°C

Additional Information:

Bafilomycin A1 is a macrolide antibiotic derived from Streptomyces griseus which is a potent and selective inhibitor of vacuolar H+-ATPases with an IC50 = 0.6 – 1.5 nM (1,2). This compound inhibits autophagy via the disruption of fusion between autophagosomes and lysosomes (3).