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Puromycin

Puromycin
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Size: 250 mg
$200.00
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Catalogue number:
10-2100-02
Name:
Puromycin
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Translation inhibitor

Data sheet:

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Applications:


Translation inhibitor

Product Type:
Biochemicals & reagents
CAS Number:
58-58-2
Storage Temp:
-20°C
Molecular Weight:
544.43
Reference:
1) Azzam and Algranati; (1973) Mechanism of puromycin action: fate of ribosomes after release of nascent polypeptide chains from polysomes Proc.Nat.Acad.Sci.USA 70 3866 / 2) Bhutani et al. (2007) Puromycin-sensitive aminopeptidase is the major peptidase responsible for digesting polyglutamine sequences by proteasomes during protein degradation EMBO J. 26 1385 / 3) Price and Verner (1993) Puromycin inhibits protein import into mitochondria by interfering with an intramitochondrial ATP-dependent reaction Biochim.Biophys.Acta 1150 89
Additional Information:
Puromycin (58-58-2) is an aminonucleoside antibiotic derived from Streptomyces alboniger. It is a protein synthesis inhibitor that disrupts peptide transfer on ribosomes causing premature chain termination.1 It is an inhibitor of dipeptidyl-peptidase II and cytosolic alanyl aminopeptidase.2 Puromycin also inhibits protein transport in mitochondria.3