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Puromycin

Supplier:
Catalogue number:
10-2100-01
Size:
50 mg
Product is available in:
  • USA
  • Canada
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Translation inhibitor

Product Type:

Biochemicals & reagents

CAS Number:

58-58-2

Range:

1) Azzam and Algranati; (1973) Mechanism of puromycin action: fate of ribosomes after release of nascent polypeptide chains from polysomes Proc.Nat.Acad.Sci.USA 70 3866 / 2) Bhutani et al. (2007) Puromycin-sensitive aminopeptidase is the major peptidase responsible for digesting polyglutamine sequences by proteasomes during protein degradation EMBO J. 26 1385 / 3) Price and Verner (1993) Puromycin inhibits protein import into mitochondria by interfering with an intramitochondrial ATP-dependent reaction Biochim.Biophys.Acta 1150 89

Limit of Detection:

544.43

Storage Temperature:

-20°C

Additional Information:

Puromycin (58-58-2) is an aminonucleoside antibiotic derived from Streptomyces alboniger. It is a protein synthesis inhibitor that disrupts peptide transfer on ribosomes causing premature chain termination.1 It is an inhibitor of dipeptidyl-peptidase II and cytosolic alanyl aminopeptidase.2 Puromycin also inhibits protein transport in mitochondria.3

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