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Catalogue number:
10 mg
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Microtubule inhibitor

Product Type:

Biochemicals & reagents

CAS Number:


Alternative Names:



1) Jordan et al. (1992), effects of vinblastine, podophyllotoxin and nocodazole on mitotic spindles. Implications for the role of microtubule dynamics in mitosis; J. Cell Science, 102 401 / 2) Storrie et al. (1998), Dynamics of the interphase mammalian Golgi complex as revealed through drugs producing reversible Golgi disassembly; Biochim. Biophys. Acta, 1404 127 / 3) Mejillano et al. (1996), Studies on the nocodazole-induced GTPase activity of tubulin; Arch. Biochem. Biophys., 336 130 / 4) Wang et al. (1998), Microtubule-interfering agents activate c-Jun N-terminal kinase/stress-activated protein kinase through both Ras and apoptosis signal-regulating kinase pathways; J. Biol. Chem., 273 4928

Limit of Detection:


Storage Temperature:

Room Temperature (des.)

Additional Information:

Nocodazole (31430-18-9) is an antimitotic agent that disrupts microtubules by binding to β tubulin and thereby inhibiting microtubule dynamics, disruption of mitotic spindle function, and fragmentation of the Golgi complex1,2. Arrests cell cycle at G2/M phase. Stimulates the intrinsic GTPase activity of tubulin3. Nocodazole activates the JNK/SAPK signaling pathway and induces apoptosis in a variety of cell lines4. Cell permeable.

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