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Antibiotic A-23187

Supplier:
Catalogue number:
10-2284-01
Size:
10 mg
Product is available in:
  • USA
  • Canada
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Ca2+ ionophore

Product Type:

Biochemicals & reagents

CAS Number:

52665-69-7

Alternative Names:

Calcimycin

Range:

1) Reed and Lardy (1972) A23187: a divalent cation ionophore, J. Biol. Chem. 247, 6970 / 2) Wong et al. (1973) Effects of antibiotic ionophore, A23187, on oxidative phosphorylation and calcium transport of liver mitochondria, Arch. Biochem. Biophys. 156 578 / 3) Hara and Kanazawa (1986) Selective inhibition by ionophore A23187 of the enzyme isomerization in the catalytic cycle of sarcoplasmic reticulum Ca2+-ATPase, J.Biol.Chem. 261 16584

Limit of Detection:

523.62

Storage Temperature:

-20°C

Additional Information:

Antibiotic A-23187 (52665-69-7) is a highly selective divalent cation ionophore, commonly used to increase intracellular Ca2+ levels in intact cells (though it is most selective for Mn2+).1 It uncouples oxidative phosphorylation.2 In addition, antibiotic A-23187 inhibits ATPase activity.3

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