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Garcinol

Catalogue number:
SM52-5
Size:
5 mg
Product is available in:
  • USA
  • Canada
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Garcinol is a polyisoprenylated benzophenone derivative from the rind of Garcinia indica fruit and is a potent inhibitor of histone acetyltransferases p300 and PCAF in-vitro. p300, also known as E1A binding protein p300, regulates cell growth and division through interacting with numerous transcription factors, and the p53 associated trancriptional coactivator PCAF (P300/CBP-associated factor) plays a direct role in transcriptional regulation. Garcinol predominantly down-regulates global gene expression in HeLa cells. Additional research shows that Garcinol exhibits anti-carcinogenic and anti-inflammatory properties through selectively suppressing Prostaglandin E2 synthesis and 5-lipoxygenase product formation. It promotes neurogenesis in corticol progenitor cells and contributes for ex-vivo expansion of human hematopoietic stem cells (hHSC).

Product Type:

Peptides & proteins

CAS Number:

78824-30-3

Alternative Names:

Camboginol, (1R,5R,7R)-3-(3,4-Dihydroxybenzoyl)-4-hydroxy-8,8-dimethyl-1,7-bis(3-methyl-2-buten-1-yl)-5-[(2S)-5-methyl-2-(1-methylethenyl)-4-hexen-1-yl]-Bicyclo[3.3.1]non-3-ene-2,9-dione

Range:

1) Nishino, T., et al. 2011. PLoS One. 6(9): e24298. PMID: 21931675; 2) Weng, MS., et al. 2011. J Agric Food Chem. 59(3): 1031-1040. PMID: 21214247

Limit of Detection:

602.8

Storage Temperature:

-20°C. Keep away from direct sunlight.

Shelf Life:

12 months from receipt