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GDC-0449

GDC-0449
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Size: 25 mg
$155.00
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Catalogue number:
SM54-25
Name:
GDC-0449
Supplier:
Availability:

GDC-0449 is a potent and specific Hedgehog signaling pathway inhibitor. GDC-0449 targets the Hedgehog signaling pathway, blocking the activities of the Hedgehog-ligand cell surface receptors PTCH and/or SMO and suppressing Hedgehog signaling. GDC-0449 prevents multiple ATP-binding cassette (ABC) transporters. GDC-0449 prevents the growth of primary pancreatic xenografts without non-specifically inhibiting pancreatic cell proliferation.

Data sheet:

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Product Type:
Peptides & proteins
CAS Number:
879085-55-9
Alternative Names:
Vismodegib, HhAntag691, 2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide
Storage Temp:
-20°C. Keep away from direct sunlight.
Molecular Weight:
421.3
Material Safety Data Sheet:
Reference:
1) Firestone, AJ. and Chen, JK. 2010. ACS Chem Biol. 5(1): 15-34. PMID: 20000447; 2) An, SM., et al. 2013. Acta Pharmacol Sin. 34(6): 777-783. PMID: 23708555
Shelf Life:
12 months from receipt