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Fasudil Hydrochloride

Catalogue number:
SM49-500
Size:
500 mg
Product is available in:
  • USA
  • Canada
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Fasudil hydrochloride is a cyclic nucleotide-dependent Rho-associated kinase inhibitor. The Rho-kinase (ROCK) mediates vasoconstriction and vascular remodeling. Fasudil effectively inhibited ISO-induced heart failure, as evaluated by biometric, hemodynamic, and histological examinations. It has been demonstrated that fasudil decrease human embryonic stem cells (hESC) dissociation-induced apoptosis, increase hESC cloning efficiency and facilitate hESC subcloning after gene transfer.

Product Type:

Peptides & proteins

CAS Number:

105628-07-7

Alternative Names:

HA-1077 hydrochloride, Eril, AT-877, 5-(1,4-diazepan1-ylsulfonyl)isoquinoline hydrochloride

Range:

1) Watanabe, K., et al. 2007. Nat Biotechnol. 25(6): 681-686. PMID: 17529971; 2) Zhang, XZ. 2010. Reprod Biomed Online. 21(1): 26-36. PMID: 20462797; 3) O, E., et al. 2011. Int J Mol Med. 28(3): 357-363. PMID: 21567077

Limit of Detection:

327.83

Storage Temperature:

-20°C. Keep away from direct sunlight.

Shelf Life:

12 months from receipt