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GDC-0449

Catalogue number:
SM54-50
Size:
50 mg
Product is available in:
  • USA
  • Canada
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GDC-0449 is a potent and specific Hedgehog signaling pathway inhibitor. GDC-0449 targets the Hedgehog signaling pathway, blocking the activities of the Hedgehog-ligand cell surface receptors PTCH and/or SMO and suppressing Hedgehog signaling. GDC-0449 prevents multiple ATP-binding cassette (ABC) transporters. GDC-0449 prevents the growth of primary pancreatic xenografts without non-specifically inhibiting pancreatic cell proliferation.

Product Type:

Peptides & proteins

CAS Number:

879085-55-9

Alternative Names:

Vismodegib, HhAntag691, 2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide

Range:

1) Firestone, AJ. and Chen, JK. 2010. ACS Chem Biol. 5(1): 15-34. PMID: 20000447; 2) An, SM., et al. 2013. Acta Pharmacol Sin. 34(6): 777-783. PMID: 23708555

Limit of Detection:

421.3

Storage Temperature:

-20°C. Keep away from direct sunlight.

Shelf Life:

12 months from receipt