Purmorphamine
Purmorphamine is an agonist of the protein Smoothened (Hh), a key part of the hedgehog signaling pathway, which is involved in bone growth and brain development as well as having a number of other functions in the body. Purmorphamine has been shown to induce osteogenesis in bone tissue as well as influencing growth and differentiation of neurons in the brain. The EC50 value for differentiation of C3H10T1/2 cells based on alkaline phosphatase expression is 1 μM.
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Peptides & proteins
8296765
9-cyclohexyl-N-(4-morpholinophenyl)-2-(naphthalen1-yloxy)-9H-purin-6-amine, 2-(1-Naphthoxy)-6-(4-morpholinoanilino)-9-cyclohexylpurine
1) Alessi, DR., et al. 1995. J Biol Chem. 270(46): 27489-27494. PMID: 7499206; 2) Dudley, DT., et al. 1995. Proc Natl Acad Sci U S A. 92(17): 7686-7689. PMID: 7644477; 3) Tsang, F., et al. 1998. Br J Pharmacol. 125(1): 61-68. PMID: 9776345; 4) Qi, X., et al. 2004. Proc Natl Acad Sci U S A. 101(16): 6027-6032. PMID: 15075392; 5) Kojima, k., et al. 2007. Cancer Res. 67(7): 3210-3219. PMID: 17409429
267.28
-20°C. Keep away from direct sunlight.
12 months from receipt