Pifithrin-μ
Supplier:
Catalogue number:
SM29-10
Size:
10 mg
Product is available in:
Pifithrin μ selectively interacts with HSP70 and disrupts its association with co-chaperones and substrate proteins. It induces apoptosis and it is cell permeable. Also, inhibits p53 binding to mitochondria by reducing its affinity for antiapoptotic proteins Bcl-2 and Bcl-XL. Pifithrin μ rescues cells from lethal γ-irradiation-induced cell death.
- Datasheet: view or download
Product Type:
Peptides & proteins
CAS Number:
64984-31-2
Alternative Names:
PFTu, NSC 303580, PIF, 2-Phenylethynesulfonamide
Range:
1) Henderson, YC., et al. 2010. Mol Cancer Ther. 9(7): 1968-1976. PMID: 20587665; 2) Ying, QL., et al. 2008. Nature. 453(7194): 519-523. PMID: 18497825
Limit of Detection:
482.19
Storage Temperature:
-20°C. Keep away from direct sunlight.
Shelf Life:
12 months from receipt