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Pifithrin-μ

Pifithrin-μ
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Size: 10 mg
$155.00
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Catalogue number:
SM29-10
Name:
Pifithrin-μ
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Pifithrin μ selectively interacts with HSP70 and disrupts its association with co-chaperones and substrate proteins. It induces apoptosis and it is cell permeable. Also, inhibits p53 binding to mitochondria by reducing its affinity for antiapoptotic proteins Bcl-2 and Bcl-XL. Pifithrin μ rescues cells from lethal γ-irradiation-induced cell death.

Data sheet:

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Product Type:
Peptides & proteins
CAS Number:
64984-31-2
Alternative Names:
PFTu, NSC 303580, PIF, 2-Phenylethynesulfonamide
Storage Temp:
-20°C. Keep away from direct sunlight.
Molecular Weight:
181.2
Material Safety Data Sheet:
Reference:
1) Strom, E., et al. 2006. Nat Chem Biol. 2: 474-479. PMID: 16862141; 2) Xu, X., et al. 2010. Biotechnol Prog. 26: 781-788. PMID: 20014103; 3) Steele, A.J., et al. 2009. Blood. 114: 1217-1225. PMID: 19515722; 4) Vaseva, A.V., et al. 2009. Cell Cycle. 8: 1711-1719. PMID: 19411846; 5) Drakos, E., et al. 2009. Leukemia. 23: 2290-2299. PMID: 19741726; 6) Hagn, F., et al. 2010. J. Biol. Chem. 285: 3439-3450. PMID: 19955567
Shelf Life:
12 months from receipt