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Pifithrin-μ

Catalogue number:
SM29-2.5
Size:
2.5 mg
Product is available in:
  • USA
  • Canada
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Pifithrin μ selectively interacts with HSP70 and disrupts its association with co-chaperones and substrate proteins. It induces apoptosis and it is cell permeable. Also, inhibits p53 binding to mitochondria by reducing its affinity for antiapoptotic proteins Bcl-2 and Bcl-XL. Pifithrin μ rescues cells from lethal γ-irradiation-induced cell death.

Product Type:

Peptides & proteins

CAS Number:

64984-31-2

Alternative Names:

PFTu, NSC 303580, PIF, 2-Phenylethynesulfonamide

Range:

1) Strom, E., et al. 2006. Nat Chem Biol. 2: 474-479. PMID: 16862141; 2) Xu, X., et al. 2010. Biotechnol Prog. 26: 781-788. PMID: 20014103; 3) Steele, A.J., et al. 2009. Blood. 114: 1217-1225. PMID: 19515722; 4) Vaseva, A.V., et al. 2009. Cell Cycle. 8: 1711-1719. PMID: 19411846; 5) Drakos, E., et al. 2009. Leukemia. 23: 2290-2299. PMID: 19741726; 6) Hagn, F., et al. 2010. J. Biol. Chem. 285: 3439-3450. PMID: 19955567

Limit of Detection:

181.2

Storage Temperature:

-20°C. Keep away from direct sunlight.

Shelf Life:

12 months from receipt