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PD98059 

PD98059 
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Size: 2 mg
$55.00
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Catalogue number:
SM28-2
Name:
PD98059 
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PD98059 is a potent and selective cell permeable inhibitor of MAP kinase (MEK). It selectively blocks the activation of MEK, thereby inhibiting the phosphorylation and the activation of MAP kinase. PD98059 inhibits cell growth and reverses the phenotype of ras-transformed BALB3T3 mouse fibroblasts and rat kidney cells. PD98059 inhibits cell growth and proliferation in acute myelogenous leukemia (AML) cell lines and causes G1 arrest by blocking p53-dependent p21 induction. This small molecule also enhances embryonic stem cell (ESC) self-renewal.

Data sheet:

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Product Type:
Peptides & proteins
CAS Number:
167869-21-8
Alternative Names:
PD 98059, 2′-Amino-3′-methoxyflavone, 2-(2-amino3-methoxyphenyl)-4H-1-Benzopyran-4-one
Storage Temp:
-20°C. Keep away from direct sunlight.
Molecular Weight:
267.28
Material Safety Data Sheet:
Reference:
1) Alessi, DR., et al. 1995. J Biol Chem. 270(46): 27489-27494. PMID: 7499206; 2) Dudley, DT., et al. 1995. Proc Natl Acad Sci U S A. 92(17): 7686-7689. PMID: 7644477; 3) Tsang, F., et al. 1998. Br J Pharmacol. 125(1): 61-68. PMID: 9776345; 4) Qi, X., et al. 2004. Proc Natl Acad Sci U S A. 101(16): 6027-6032. PMID: 15075392; 5) Kojima, k., et al. 2007. Cancer Res. 67(7): 3210-3219. PMID: 17409429
Shelf Life:
12 months from receipt