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RG108 

RG108 
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Size: 2 mg
$55.00
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Catalogue number:
SM31-2
Name:
RG108 
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RG108 is a non-nucleoside DNA methyltransferase (DMNT) inhibitor. RG108 effectively blocked DNA methyltransferases in-vitro and does not cause covalent enzyme trapping in human cell lines. RG108 significantly reduces the methylation of genomic DNA in cells at 10 μM without detectable toxicity, distinguishing it from nucleoside-based inhibitors like 5-azacytidine. Through these actions, RG108 demethylates and reactivates epigenetically silenced tumor suppressor genes. RG108 inhibits human tumor cell line (HCT116, NALM-6) proliferation and increased doubling time in culture.

Data sheet:

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Product Type:
Peptides & proteins
CAS Number:
48208-26-0
Alternative Names:
RG 108, DNA Methyltransferase Inhibitor, N-PhthalylL-tryptophan
Storage Temp:
-20°C. Keep away from direct sunlight.
Molecular Weight:
334.33
Material Safety Data Sheet:
Reference:
1) Brueckner, B., et al. 2005. Cancer Res. 65(14): 6305-6311. PMID: 16024632; 2) Stresemann, C., et al. 2006. Cancer Res. 66(5): 2794-2800. PMID: 16510601; 3) Schirrmacher, E., et al. 2006. Bioconjug Chem.17(2): 261-266. PMID: 16536454
Shelf Life:
12 months from receipt