SB203580 is a specific inhibitor of p38-MAPK pathway. SB203580 also inhibits protein kinase B (PKB, also known as Akt) and TLR signaling pathway. SB203580 inhibits the IL-2-induced proliferation of primary human T cells, murine CT6 T cells, or BAF F7 B cells with an IC50 of 3 - 5 μM. SB203580 suppresses the development of endometriosis by down-regulating proinflammatory cytokines and proteolytic factors in a mouse model. It is a new reversal agent of P-glycoprotein-mediated multidrug resistance.
Peptides & proteins
RWJ 64809, PB 203580, 4-[4-(4-fluorophenyl)-2-[4-methylsulfinyl)phenyl]-1H-imidazol-5-yl]-pyridine
1) Cuenda, A., et al. 1995. FEBS Lett. 364(2): 229-233. PMID: 7750577; 2) Lali, FV., et al. 2000. J Biol Chem. 275(10): 7395-7402. PMID: 10702313; 3) Jarnicki, AG., et al. 2008. J Immunol. 180(6): 3797-3806. PMID: 18322186
-20°C. Keep away from direct sunlight.
12 months from receipt