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RG108 

Catalogue number:
SM31-50
Size:
50 mg
Product is available in:
  • USA
  • Canada
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RG108 is a non-nucleoside DNA methyltransferase (DMNT) inhibitor. RG108 effectively blocked DNA methyltransferases in-vitro and does not cause covalent enzyme trapping in human cell lines. RG108 significantly reduces the methylation of genomic DNA in cells at 10 μM without detectable toxicity, distinguishing it from nucleoside-based inhibitors like 5-azacytidine. Through these actions, RG108 demethylates and reactivates epigenetically silenced tumor suppressor genes. RG108 inhibits human tumor cell line (HCT116, NALM-6) proliferation and increased doubling time in culture.

Product Type:

Peptides & proteins

CAS Number:

48208-26-0

Alternative Names:

RG 108, DNA Methyltransferase Inhibitor, N-PhthalylL-tryptophan

Range:

1) Brueckner, B., et al. 2005. Cancer Res. 65(14): 6305-6311. PMID: 16024632; 2) Stresemann, C., et al. 2006. Cancer Res. 66(5): 2794-2800. PMID: 16510601; 3) Schirrmacher, E., et al. 2006. Bioconjug Chem.17(2): 261-266. PMID: 16536454

Limit of Detection:

334.33

Storage Temperature:

-20°C. Keep away from direct sunlight.

Shelf Life:

12 months from receipt