Linopirdine dihydrochloride
Kv7 blocker / Linopirdine increases acetylcholine release and improves performance in animal models of learning and memory via blockade of Kv7 (KCNQ) voltage-gated potassium channels.1-3 Linopirdine is a state-dependent blocker favoring activated single subunits of the channel.4 It has also been shown to act as an agonist of TRPV1.5
Biochemicals & reagents
113168-57-3
DuP 996
1) Kristufek (1999), Modulation of spontaneous and stimulation-evoked transmitter release from rat sympathetic neurons by the cognition enhancer linopirdine: insights into its mechanisms of action; J. Neurochem. 72 2083 2) Wang et al. (1998), KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel; Science 282 1890 3) Fontana et al. (1994), Linopirdine (DuP 996) improves performance in several tests of learning and memory by modulation of cholinergic neurotransmission; Pharmacol. Biochem. Behav. 49 1075 4) Greene et al. (2017), XE991 and Linopirdine Are State-Dependent Inhibitors of Kv7/KCNQ Channels that Favor Activated Subunits; J. Pharmacol. Exp. Ther. 362 177 5) Neascu and Babes (2010), The M-channel blocker linopirdine is an agonist of the capsaicin receptor TRPV1; J. Pharmacol. Sci. 114 332
-20°C
TARGET: Ion channel -- PATHWAY: Cation channel; ACh (Acetylcholine) signaling -- RESEARCH AREA: Neuroscience -- DISEASE AREA: Neurodegeneration; Ageing