Nimodipine
L-type calcium channel blocker / An L-type calcium channel blocker.1 Prevents age-induced learning deficits in a rat model.2 Facilitates recovery of function after brain damage3 and displays neuroprotective effects4. Promotes remyelination in a mouse model of multiple sclerosis.5 In clinical use for reduction of cerebral vasospasm following subarachnoid hemorrhage.6
Biochemicals & reagents
66085-59-4
Bay-e 9736
1) Cohen and McCarthy (1987), Nimodipine block of calcium channels in rat anterior pituitary cells; J. Physiol., 387 195 2) Batuecas et al. (1998), Effects of chronic nimodipine on working memory of old rats in relation to defects in synaptosomal calcium homeostasis; Eur. J. Pharmacol., 350 141 3) LeVere et al. (1989), Recovery of function after brain damage: facilitation by the calcium entry blocker nimodipine; Behav. Neurosci., 103 561 4) Herzfeld et al. (2014), Investigation of the neuroprotective impact of nimodipine on Neuro2a cells by means of a surgery-like stress model; Int. J. Mol. Sci., 15 18453 5) Schampel et al. (2017), Nimodipine fosters remyelination in a mouse model of multiple sclerosis and induces microglia-specific apoptosis; Proc. Natl. Acad. Sci. USA, 114 E3295 6) Allen et al. (1983), Cerebral arterial spasm - a controlled trial of nimodipine in patients with subarachnoid hemorrhage; N. England J. Med., 308 619
RT
TARGET: Ion channel -- PATHWAY: Calcium signaling; Autophagy -- RESEARCH AREA: Neuroscience; Cell death; Immunology -- DISEASE AREA: Neurodegeneration