Isradipine
L-type Ca channel blocker / L-type calcium channel blocker. Displays antiatherosclerotic effects and improves endothelium-mediated nitric oxide-dependent vasodilation. Displays neuroprotective activity in rat models. Orally active and cell permeable
Biochemicals & reagents
75695-93-1
1) Bracht et al. (2001), Isradipine improves endothelium-dependent vasodilation in normotensive coronary artery disease patients with hypercholesterolemia; J. Hyperten., 19 899. / 2) Chandra et al. (1999), Use of diffusion-weighted MRI and neurological deficit scores to demonstrate beneficial effects of isradipine in a rat model of focal ischemia ; Pharmacology, 58 292 / 3) Merck 14:5240
RT
TARGET: Ion channel -- PATHWAY: Calcium signaling -- RESEARCH AREA: Neuroscience -- DISEASE AREA: Neurodegeneration; Atherosclerosis