Gabapentin
Neuropathic pain drug / Gabapentin is an approved drug for treatment of various types of neuropathic pain and some forms of epilepsy. The mechanism of action of gabapentin is not well understood. Despite being a structural mimic of GABA, it does not bind to GABA receptors at concentrations up to 1 mM.1,2 Some of its actions may be due to disrupting calcium channels.3
Biochemicals & reagents
60142-96-3
Neurontin
1) Cheng et al. (2004), Does gabapentin act as an agonist at native GABA(B) receptors?; J.Biomed.Sci. 11 346 2) Lanneau et al. (2001), Gabapentin is not a GABAB receptor agonist; Neuropharmacology 41 965 3) Hendrich et al. (2008), Pharmacological disruption of calcium channel trafficking by the alpha2delta ligand gabapentin; Proc.Natl.Acad.Sci.USA 105 3628
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TARGET: Ion channel -- PATHWAY: Calcium signaling -- RESEARCH AREA: Neuroscience -- DISEASE AREA: Pain