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ICA-121431

Supplier:
Catalogue number:
10-4085-02
Size:
25 mg
Product is available in:
  • USA
  • Canada
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Nav1.1/1.3 inhibitor (selective) / Selective Nav1.1/1.3 inhibitor (hIC50s = 23 and 13 nM respectively; also selective for dog, monkey, and mouse, but not rat).1 It exclusively shifts voltage dependence to more negative voltages and accelerates entry into slow activation.2

Product Type:

Biochemicals & reagents

CAS Number:

313254-51-2

Reference:

McCormack et al. (2013), Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels; Proc. Natl. Acad. Sci. USA 110 E2724 Ostenn et al. (2017), Pharmacology of the Nav1.1 domain IV voltage sensor reveals coupling between inactivation gating processes; Proc. Natl. Acad. Sci. USA 114 6836

Storage Temperature:

-20°C

Additional Information:

TARGET: Ion channel -- PATHWAY: Cation channel -- RESEARCH AREA: Neuroscience -- DISEASE AREA: Pain