Polygodial
TRPA1 agonist / TRPA1 agonist (EC50=400 nM)1. A naturally occurring drimane sesquiterpene dialdehyde found in a variety of plant species including water pepper (Polygonum hydropiper). Has been used in folk medicine for a variety of indications. Displays analgesic activity via desensitization of sensory neurons2.
Biochemicals & reagents
6754-20-7
1) Escalera et al. (2008), TRPA1 mediates the noxious effects of natural sesquiterpene deterrents; J. Biol. Chem., 283 24136 / 2) Andre et al. (2004), Evidence for the involvement of vanilloid receptor in the antinociception produced by the dialdehydes unsaturated sesquiterpenes polygodial and drimanial in rats; Neuropharmacology, 46 590
-20°C
TARGET: Ion channel -- PATHWAY: Cation channel -- RESEARCH AREA: Neuroscience -- DISEASE AREA: Pain