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Polygodial

Supplier:
Catalogue number:
10-1145-02
Size:
25 mg
Product is available in:
  • USA
  • Canada
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TRPA1 agonist / TRPA1 agonist (EC50=400 nM)1. A naturally occurring drimane sesquiterpene dialdehyde found in a variety of plant species including water pepper (Polygonum hydropiper). Has been used in folk medicine for a variety of indications. Displays analgesic activity via desensitization of sensory neurons2.

Product Type:

Biochemicals & reagents

CAS Number:

6754-20-7

Reference:

1) Escalera et al. (2008), TRPA1 mediates the noxious effects of natural sesquiterpene deterrents; J. Biol. Chem., 283 24136 / 2) Andre et al. (2004), Evidence for the involvement of vanilloid receptor in the antinociception produced by the dialdehydes unsaturated sesquiterpenes polygodial and drimanial in rats; Neuropharmacology, 46 590

Storage Temperature:

-20°C

Additional Information:

TARGET: Ion channel -- PATHWAY: Cation channel -- RESEARCH AREA: Neuroscience -- DISEASE AREA: Pain