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Isopimaric acid

Supplier:
Catalogue number:
10-5487-01
Size:
5 mg
Product is available in:
  • USA
  • Canada
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Potassium channel activator / Terpenoid acid that activates BK (voltage-gated potassium) channels when used at 10 µM in HEK293 cells.1 Improves spatial and non-spatial memory in Alzheimer’s mouse model2,3, and significantly improves motor function in a rat spinal cord injury model4. Reduces hyperactivity of spontaneously active auditory networks, EC50=7.8 uM.5

Product Type:

Biochemicals & reagents

CAS Number:

5835-26-7

Reference:

1) Imaizumi et al. (2002), Molecular basis of pimarane compounds as covel activators of large-conductance CA(2+)-activated K(+) channel alpha-subunit; Mol. Phamracol., 62 836 2) Wang et al. (2015), Cognitive recovery by chronic activation of the large-conductance calcium-activated potassium channel in a mouse model of Alzheimer's disease; Neuropharmacology, 92 8 3) Wang et al. (2015), Improvement of spatial learning by facilitating large-conductance calcium-activated potassium channel with transcranial magnetic stimulation in Alzheimer's disease model mice; Neuropharmacology, 97 210 4) Jacobsen et al. (2018), Activation of the Large-conductance, Voltage, and Ca2+-Activated K+ (BK) Channel in Acute Spinal Cord Injury in the Wistar Rat is Neuroprotective; Front. Neurol., 9 1107 5) Wu et al. (2014), Pharmacodynamics of potassium channel openers in cultured neuronal networks; Eur. J. Pharmacol., 732 68

Storage Temperature:

-20°C

Additional Information:

TARGET: Ion channel -- PATHWAY: Potassium channel -- RESEARCH AREA: Neuroscience -- DISEASE AREA: Neurodegeneration; Ageing