Isopimaric acid
Potassium channel activator / Terpenoid acid that activates BK (voltage-gated potassium) channels when used at 10 µM in HEK293 cells.1 Improves spatial and non-spatial memory in Alzheimer’s mouse model2,3, and significantly improves motor function in a rat spinal cord injury model4. Reduces hyperactivity of spontaneously active auditory networks, EC50=7.8 uM.5
Biochemicals & reagents
5835-26-7
1) Imaizumi et al. (2002), Molecular basis of pimarane compounds as covel activators of large-conductance CA(2+)-activated K(+) channel alpha-subunit; Mol. Phamracol., 62 836 2) Wang et al. (2015), Cognitive recovery by chronic activation of the large-conductance calcium-activated potassium channel in a mouse model of Alzheimer's disease; Neuropharmacology, 92 8 3) Wang et al. (2015), Improvement of spatial learning by facilitating large-conductance calcium-activated potassium channel with transcranial magnetic stimulation in Alzheimer's disease model mice; Neuropharmacology, 97 210 4) Jacobsen et al. (2018), Activation of the Large-conductance, Voltage, and Ca2+-Activated K+ (BK) Channel in Acute Spinal Cord Injury in the Wistar Rat is Neuroprotective; Front. Neurol., 9 1107 5) Wu et al. (2014), Pharmacodynamics of potassium channel openers in cultured neuronal networks; Eur. J. Pharmacol., 732 68
-20°C
TARGET: Ion channel -- PATHWAY: Potassium channel -- RESEARCH AREA: Neuroscience -- DISEASE AREA: Neurodegeneration; Ageing