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Rufinamide

Supplier:
Catalogue number:
10-4275-02
Size:
50 mg
Product is available in:
  • USA
  • Canada
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Anticonvulsant / Improves cognition / Rufinamide is a clinically useful anticonvulsant medication.1 Its mechanism of action is believed to be inhibition of Nav1.1 and Nav1.6 activation.2 Rufinamide improved cognitive function and increased neurogenesis in gerbils via increases in IGF-1, IGF-1R, and p-CREB.3

Product Type:

Biochemicals & reagents

CAS Number:

106308-44-5

Reference:

1) Hakimian et al. (2007), Rufinamide: a new anti-epileptic medication; Expert Opin.Pharmacother. 8 1931 2) Gilchrist et al. (2014), Nav1.1 Modulation by a Novel Triazole Compound Attenuates Epileptic Seizures in Rodents; ACS Chem.Biol. 9 1204 3) Chen et al. (2018), Rufinamide, an antiepileptic drug, improves cognition and increases neurogenesis in the aged gerbil hippocampal dentate gyrus via increasing expressions of IGF-1, IGF-1R and p-CREB; Chem.Biol.Interact. 286 71

Storage Temperature:

-20°C

Additional Information:

TARGET: Ion channel -- PATHWAY: Sodium channel -- RESEARCH AREA: Neuroscience -- DISEASE AREA: Neurodegeneration