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Catalogue number:
5 mg
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Antiviral agent

  • Applications:Remdesivir active metabolite with attributes more appropriate to SARS-CoV-2 compared to Remdisivir
Product Type:

Biochemicals & reagents

CAS Number:



1) Cho, et al. (2012), Synthesis and antiviral activity of a series of 1'-substituted 4-aza-7,9-dideazaadenosine C-nucleosides; Bioorg. Med. Chem. Lett. 22 2705 2) Yan and Muller (2020), Advantages of the Parent Nucleoside GS-441524 over Remdesivir for Covid-19 Treatment; ACS Med. Chem. Lett. 11 1361

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Additional Information:

GS-441524 is the parent nucleoside and active metabolite of the SARS-CoV2 drug remdesivir. Displayed broad spectrum antiviral activity against HCV, YFV, DENV-2, influenza A, parainfluenza 3, and SARS-CoV.1 It has been suggested that GS-441524 is superior as an anti-SARS-CoV2 drug due to simplicity of preparation compared to remdesivir, lack of on-target liver toxicity, and the fact that remdesivir is prematurely hydrolysed to GS-441524 in human serum.2 Additionally, the enzymes that hydrolyze remdesivir to active metabolite GS-441524 are hardly expressed in lungs.

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