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ML300

Supplier:
Catalogue number:
10-3961-02
Size:
50 mg
Product is available in:
  • USA
  • Canada
$250.00 Shipping is calculated in checkout

Protease inhibitor: SARS-CoV chymotrypsin-like protease (3CLpro, Mpro, Nsp5)

  • Applications:Inhibits key SARS-CoV protease (Nsp5) that has 99% similarity overall to that of SARS-CoV-2.
Product Type:

Biochemicals & reagents

Range:

1) Turlington, et al. (2012), Non-covalent triazol-based inhibitors of the SARS main protease 3CLpro; In: Probe Reports from the NIH Molecular Libraries Program 2) Turlington et al. (2013), Discovery of N-(Benzo[1,2,3]triazol-1-yl)-N-(benzyl)acetamido)phenyl)carboxamides as severe acute respiratory syndrome coronavirus (SARS-CoV)3CLpro inhibitors: Identification of ML300 and noncovalent nanomolar inhibitors with an induced-fit binding; Bioorg. Med. Chem. Lett. 23 6172

Limit of Detection:

431.51

Storage Temperature:

-20°C (des.)

Additional Information:

ML300 is a selective non-covalent inhibitor of SARS-CoV 3CL protease (IC50 = 4.11 µM).1,2

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