IM-12 is a cell-permeable indolylmaleimide that acts as a Glycogen synthase kinase 3 beta (GSK-3 beta) inhibitor, activating downstream components of canonical Wnt signaling. IM-12 significantly increases beta-catenin levels. IM-12 leads to TCF-induction and promotes neuronal differentiation in human neural progenitor cells by activating Wnt pathway. IM-12 when combined with other small molecules supports the self-renewal of naive human embryonic stem cells and maintenance of ground state pluripotency.
Peptides & proteins
GSK-3β Inhibitor, GSK-3 beta, 3-(4-Fluorophenylethylamino)-1-methyl-4-(2-methyl-1Hindol-3-yl)-1H-pyrrole-2,5-dione
1) Schmole, AC., et al. 2010. Bioorg Med Chem. 18(18): 6785-6795. PMID: 20708937; 2) Theunissen, TW. et al. 2014. Cell Stem Cell. 15(4): 471-487. PMID: 25090446
-20°C. Keep away from direct sunlight.
12 months from receipt