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5-Azacytidine

5-Azacytidine
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Size: 50 mg
$55.00
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Catalogue number:
SM07-50
Name:
5-Azacytidine
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5-Azacytidine is an epigenetic modifier, a potent growth inhibitor and a cytotoxic agent. 5-Azacytidine acts as a demethylating agent by inhibiting DNA methyltransferase (DNMT), forming covalent adducts with cellular DNMT1 depleting enzyme activity. This small molecule enhances differentiation to cardiomyocytes from human embryonic stem cells. 5-Azacytidine also increases reprogramming efficiency of mouse fibroblasts to pluripotent stem cells.

Data sheet:

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Product Type:
Peptides & proteins
CAS Number:
320-67-2
Alternative Names:
5-AzaC, Ladakamycin, NSC 103-627, NSC 102816, U 18496, WR 183027, Zcyd, 4-Amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3,5-triazin-2-one
Storage Temp:
-20°C. Keep away from direct sunlight.
Molecular Weight:
244.2
Material Safety Data Sheet:
Reference:
1) Kusaba, H., et al.1999. Eur J Biochem. 262(3): 924-932. PMID: 10411657; 2) Broday, L., et al.1999. Mol Cell Biol. 19(4): 3198-3204. PMID: 10082586; 3) Yoon, BS., et al. 2006. Differentiation. 74(4): 149-159. PMID: 16683985; 4) Mikkelsen, TS., et al. 2008. Nature. 454(7200): 49-55. PMID: 18509334
Shelf Life:
12 months from receipt