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5-Azacytidine

Catalogue number:
SM07-200
Size:
200 mg
Product is available in:
  • USA
  • Canada
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5-Azacytidine is an epigenetic modifier, a potent growth inhibitor and a cytotoxic agent. 5-Azacytidine acts as a demethylating agent by inhibiting DNA methyltransferase (DNMT), forming covalent adducts with cellular DNMT1 depleting enzyme activity. This small molecule enhances differentiation to cardiomyocytes from human embryonic stem cells. 5-Azacytidine also increases reprogramming efficiency of mouse fibroblasts to pluripotent stem cells.

Product Type:

Peptides & proteins

CAS Number:

320-67-2

Alternative Names:

5-AzaC, Ladakamycin, NSC 103-627, NSC 102816, U 18496, WR 183027, Zcyd, 4-Amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3,5-triazin-2-one

Range:

1) Kusaba, H., et al.1999. Eur J Biochem. 262(3): 924-932. PMID: 10411657; 2) Broday, L., et al.1999. Mol Cell Biol. 19(4): 3198-3204. PMID: 10082586; 3) Yoon, BS., et al. 2006. Differentiation. 74(4): 149-159. PMID: 16683985; 4) Mikkelsen, TS., et al. 2008. Nature. 454(7200): 49-55. PMID: 18509334

Limit of Detection:

244.2

Storage Temperature:

-20°C. Keep away from direct sunlight.

Shelf Life:

12 months from receipt