IM-12
Supplier:
Catalogue number:
SM04-25
Size:
25 mg
Product is available in:
IM-12 is a cell-permeable indolylmaleimide that acts as a Glycogen synthase kinase 3 beta (GSK-3 beta) inhibitor, activating downstream components of canonical Wnt signaling. IM-12 significantly increases beta-catenin levels. IM-12 leads to TCF-induction and promotes neuronal differentiation in human neural progenitor cells by activating Wnt pathway. IM-12 when combined with other small molecules supports the self-renewal of naive human embryonic stem cells and maintenance of ground state pluripotency.
Product Type:
Peptides & proteins
CAS Number:
1129669-05-1
Alternative Names:
GSK-3β Inhibitor, GSK-3 beta, 3-(4-Fluorophenylethylamino)-1-methyl-4-(2-methyl-1Hindol-3-yl)-1H-pyrrole-2,5-dione
Storage Temperature:
at -20°C
Shelf Life:
at least 12 months