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A-803467

Supplier:
Catalogue number:
10-1066-01
Size:
10 mg
Product is available in:
  • USA
  • Canada
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NaV1.8 blocker / Potent, selective inhibitor of the TTX-resistant voltage-gated sodium channel Nav1.8. Nav1.8 is preferentially expressed in sensory neurons, and inhibition attenuates both inflammatory and neuropathic pain in a variety of animal models. IC50's for rat and human Nav1.8 are 140 nM and 8.0 nM respectively.

Product Type:

Biochemicals & reagents

CAS Number:

944261-79-4

Reference:

1) Jarvis et al. (2007), A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat; Proc. Natl. Acad. Sci. USA, 104 8520 / 2) McGaraughty et al. (2008), A selective Nav1.8 sodium channel blocker, A-803467 [5-(4-chlorophenyl-N-(3,5-dimethoxyphenyl)furan-2-carboxamide], attenuates spinal neuronal activity in neuropathic rats; J. Pharmacol. Exp. Ther., 324 1204

Storage Temperature:

RT

Additional Information:

TARGET: Ion channel -- PATHWAY: Sodium channel -- RESEARCH AREA: Neuroscience -- DISEASE AREA: Inflammation; Pain