1-EBIO
K+ channel activator; Cardiomyocyte differentiation / A direct activator of small-conductance Ca2+-activated K+ channels (SK) which dose-dependently relaxes rat mesenteric vessels.1 Reverses ischemia-induced cognitive impairment2 and displays neuroprotective effects in ischemia-induced neuronal cell death3. Induces embryonic stem cell differentiation into cardiomyocytes and enrichment of pacemaker-like cells.4 Induces production of superoxide and hydrogen peroxide in neutrophils with subsequent apoptosis.5
Biochemicals & reagents
10045-45-1
1-Ethylbenzimidazolinone
1) Adeagbo et al. (1999), 1-Ethyl-2-benzimidazolinone stimulates endothelial K(Ca) channels and nitric oxide formation in rat mesenteric vessels; Eur. J. Pharmacol., 379 151 2) Orfila et al. (2014), Increasing small conductance Ca2+-activated potassium channel activity reverses ischemia-induced impairment of long-term potentiation; Eur. J. Neurosci., 40 3179 3) Allen et al. (2011), SK2 channels are neuroprotective for ischemia-induced neuronal cell death; J. Cereb. Blood Flow Metab., 31 2302 4) Muller et al. (2012), Ca2+ activated K channels-new tools to induce cardiac commitment from pluripotent stem cells in mice and men; Stem Cell Rev., 8 720 5) Fay et al. (2006), SK channels mediate NADPH oxidase-independent reactive oxygen species production and apoptosis in granulocytes; Proc. Natl. Acad. Sci. USA, 103 17548
RT
TARGET: Ion channel -- PATHWAY: Apoptosis inducer; Redox; Potassium channel -- RESEARCH AREA: Stem cells; Neuroscience; Cell death; Oxidative stress -- DISEASE AREA: Ischemia; Neurodegeneration