www.mayflowerbio.com
Sales & Support: 314-485-5210

*

AC1903

Supplier:
Catalogue number:
10-3375-01
Size:
10 mg
Product is available in:
  • USA
  • Canada
$70.00 Shipping is calculated in checkout

TRPC5 blocker / A potent and selective TRPC5 blocker. Suppresses severe proteinuria and prevents podocyte loss in a transgenic rat model of focal segmental glomerulosclerosis. It also provided therapeutic benefit in a rat model of hypertensive proteineuric kidney disease. The use of this selective tool compound provided a mechanistic rationale for targeting TRPC5 channels in progressive chronic kidney diseases and paves the way for the discovery of new therapeutics. Active in vivo.

Product Type:

Biochemicals & reagents

CAS Number:

831234-13-0

Reference:

1) Zhou et al. (2017), A small-molecule inhibitor of TRPC5 ion channels suppresses progressive kidney disease in animal models; Science, 358 1332

Storage Temperature:

-20°C

Additional Information:

TARGET: Ion channel -- PATHWAY: Cation channel -- DISEASE AREA: Kidney disease