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Capsaicin (natural)

Supplier:
Catalogue number:
10-2298-02
Size:
1 g
Product is available in:
  • USA
  • Canada
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TRPV1 agonist / Capsaicin is a vanilloid agonist known to activate the transient receptor potential channel vanilloid subfamily member 1 (TRPV1)1,2 and to possess analgesic3, anti-inflammatory4 and hypolocomotor effects5. SEVERE IRRITANT - HANDLE WITH CARE

Product Type:

Biochemicals & reagents

CAS Number:

404-86-4

Reference:

1) Gunthorpe et al. (2002) The diversity in the vanilloid (TRPV) receptor family of ion channels. Trends Pharmacol. Sci. 23 183 / 2) Van Der Stelt and Di Marzo (2004) Endovanilloids. Putative endogenous ligands of transient receptor potential vanilloid 1 channels. Eur. J. Biochem. 271 1827 / 3) Perkins and Campbell (1992) Capsazepine reversal of the antinociceptive action of capsaicin in vivo. Br. J. Pharmacol. 107 329 / 4) Kim et al..(2003) Capsaicin exhibits anti-inflammatory property by inhibiting IkB-a degradation in LPS-stimulated peritoneal macrophages. Cell. Signal.;15 299 / 5) Di Marzo et al. (2001). Hypolocomotor effects in rats of capsaicin and two long chain capsaicin homologues. Eur. J. Pharmacol. ;420 123

Storage Temperature:

RT

Additional Information:

TARGET: Ion channel -- PATHWAY: Cation channel; Autophagy -- RESEARCH AREA: Neuroscience; Cell death -- DISEASE AREA: Inflammation; Pain