YM-58483
CRAC channel blocker / YM-58483 is a CRAC (calcium release-activated calcium) channel blocker1, a prototypic store-operated calcium channel2. Inhibits antigen-induced histamine release via modulation of mast cell responses.3 Displays potent analgesic actions in various pain models in mice and is orally active.4 Inhibits T cell-mediated immune responses in vivo.5
Biochemicals & reagents
223499-30-7
BTP2
1. Zitt et al. (2004), Potent inhibition of Ca2+ release-activated Ca2+ channels and T-lymphocyte activation by the pyrazole derivative BTP2; J. Biol. Chem. 279 12427 2. Prakriya et al. (2015), Store-Operated Calcium Channels; Physiol. Rev. 95 1383 3. Law et al. (2011), Structural requirements for the inhibition of calcium mobilization and mast cell activation by the pyrazole derivative BTP2; Int. J. Biochem. Cell Biol. 43 1228 4. Gao et al. (2013), Potent analgesic effects of a store-operated calcium channel inhibitor; Pain 154 2034 5. Ohga et al. (2008), Characterization of YM-58483/BTP2, a novel store-operated Ca2+ entry blocker, on T cell-mediated immune response in vivo; Int. Immunopharmacol. 8 1787
-20°C
TARGET: Ion channel -- PATHWAY: Cation channel; Calcium signaling; Cytokine; Leukotriene -- RESEARCH AREA: Immunology -- DISEASE AREA: Inflammation; Pain