Pinacidil
Potassium channel opener / Activates ATP-dependent potassium channels.1,2 Induces vascular relaxation and antihypertensive effects.3 Prevents the loss of mitochondrial inner membrane potential, protecting cerebellar granule neurons from apoptosis induced by oxidative stress.4 Displays protective effects in Parkinson’s disease models5 and cerebral ischemia-reperfusion6.
Biochemicals & reagents
85371-64-8
1) Hermsmeyer et al. (1988), Pinacidil actions on ion channels in vascular muscle; J. Cardiovasc. Pharmacol., 12(Suppl. 2) S17 2) Gollasch et al. (1995), Pinacidil relaxes porcine and human coronary arteries by activating ATP-dependent potassium channels in smooth muscle cells; J. Phamracol. Exp. Therap., 275 681 3) Cohen & Kurz (1988), Pinacidil-induced vascular relaxation: comparison to other vasodilators and to classical mechanisms of vasodilation; J. Cardiovasc. Pharmacol., 12(Suppl. 2) S5 4) Teshima et al. (2003), Mitochondrial ATP-sensitive potassium channel activation protects cerebellar granule neurons from apoptosis induced by oxidative stress; Stroke, 34 1796 5) Xie et al. (2010), K(ATP) channel openers protect mesencephalic neurons against MPP+-induced cytotoxicity via inhibition of ROS protection; J. Neurosci. Res., 88 428 6) Zhang et al. (2008), Effects of ATP sensitive potassium channel opener on the mRNA and protein expressions of caspase-12 after cerebral ischemia-reperfusion in rats; Neurosci. Bull., 24 7
RT
TARGET: Ion channel -- PATHWAY: Apoptosis inhibitor; Mitochondrial function; Potassium channel -- RESEARCH AREA: Oxidative stress; Neuroscience; Cell death -- DISEASE AREA: Hypertension; Ischemia